Thörig L, Wijngaards G, Van Haeringen N J
Ophthalmic Res. 1983;15(5):268-76. doi: 10.1159/000265270.
Human tear fluid has plasminogen activator activity. The type of plasminogen activator activity in unstimulated and stimulated tears was determined, using antibodies that specifically neutralize tissue plasminogen activator or urokinase. All plasminogen activator activity was tissue plasminogen activator-related in both types of tears. Correlations between activities of beta-hexosaminidase, lysozyme and lactate dehydrogenase with tissue plasminogen activator activity indicate that the contribution to plasminogen activator activity of conjunctival and corneal epithelium is more important in unstimulated tears than stimulated tears. In stimulated tears the tissue plasminogen activator activity originates mainly from the lacrimal gland. It is suggested that a constant concentration of plasminogen activator is released from the lacrimal gland and that this concentration is independent of the secretion rate of tear fluid and that the release from the conjunctiva is due to desquamation of cells.
人泪液具有纤溶酶原激活物活性。使用能特异性中和组织纤溶酶原激活物或尿激酶的抗体，测定了未刺激泪液和刺激泪液中纤溶酶原激活物活性的类型。两种类型的泪液中所有纤溶酶原激活物活性均与组织纤溶酶原激活物相关。β-己糖胺酶、溶菌酶和乳酸脱氢酶活性与组织纤溶酶原激活物活性之间的相关性表明，在未刺激的泪液中，结膜和角膜上皮对纤溶酶原激活物活性的贡献比刺激泪液中更重要。在刺激泪液中，组织纤溶酶原激活物活性主要来源于泪腺。提示泪腺释放的纤溶酶原激活物浓度恒定，且该浓度与泪液分泌速率无关，结膜释放是由于细胞脱屑所致。
