Holtzman N A, Faden R, Chwalow A J, Horn S D
Pediatrics. 1983 Dec;72(6):807-12.
To determine whether knowledge was improved as a result of obtaining informed consent from parents for newborn screening of their infants for phenylketonuria (PKU) and other hereditary metabolic disorders, new mothers in seven Maryland hospitals were interviewed either before receiving a standard disclosure (n = 210) or after giving consent (n = 418). The mean knowledge score of the women interviewed after giving consent was significantly higher (P less than .001). Receiving the disclosure was a more powerful predictor of knowledge score, accounting for 40% of the variance, than demographic factors, which accounted for 9%. Women whose consent was obtained just prior to discharge tended to have lower knowledge scores than women whose consent was obtained earlier (P = .03). Women with higher knowledge scores were somewhat less likely to favor consent than women with lower scores. Although consent may not be appropriate for some low-risk procedures, informing parents can be easily and inexpensively accomplished.
为了确定因父母就新生儿苯丙酮尿症（PKU）及其他遗传性代谢疾病筛查给予知情同意后知识水平是否得到提高，对马里兰州七家医院的初产妇进行了访谈，一部分是在接受标准信息披露之前（n = 210），另一部分是在给予同意之后（n = 418）。给予同意后接受访谈的女性的平均知识得分显著更高（P小于0.001）。与占9%差异的人口统计学因素相比，接受信息披露是知识得分更有力的预测因素，占差异的40%。在出院前刚刚获得同意的女性往往比更早获得同意的女性知识得分更低（P = 0.03）。知识得分较高的女性比得分较低的女性稍微不太可能赞成同意。尽管对于某些低风险程序同意可能不合适，但告知父母可以轻松且低成本地完成。
