Combs A B, Lewandowski E, Kappel M, Vadhanavikit S, Folkers K
Res Commun Chem Pathol Pharmacol. 1983 Oct;42(1):107-12.
The literature establishes a potential link between the function of tetrahydroisoquinolines in the biological actions of alcohol and the reduced pterin cofactor needed for synthesis of certain neurotransmitters. The effect of the administration of 6-methyltetrahydropterin and tetrahydrobiopterin upon alcohol withdrawal in mice was tested. Dependence was produced by ip administration of alcohol, supplemented by alcohol delivered by a subcutaneously implanted silastic tube. Administration of the reduced pterins at relatively high doses did not reduce the magnitude of the alcohol withdrawal syndrome.
