Kendler K S, Robinette C D
Am J Psychiatry. 1983 Dec;140(12):1551-63. doi: 10.1176/ajp.140.12.1551.
The authors present a 16-year update on schizophrenia in the National Academy of Sciences-National Research Council (NAS-NRC) Twin Registry. As of October 1981, a recorded diagnosis of schizophrenia was equally common in monozygotic and dizygotic twins. However, probandwise concordance for schizophrenia was significantly greater in monozygotic (30.9%) than in dizygotic (6.5%) twins. Biases in zygosity determination, diagnosis, or ascertainment could not plausibly explain these results. Correction for selection effects in construction of the registry produced concordance rates for schizophrenia approaching those found in previous studies. According to registry data, genetic factors appear at least as important in the etiology of schizophrenia as in several common medical conditions, including diabetes and hypertension. Results from the NAS-NRC Twin Registry support the etiologic importance of genetic factors in schizophrenia.
作者们展示了美国国家科学院 - 国家研究委员会（NAS - NRC）双胞胎登记处关于精神分裂症的16年更新情况。截至1981年10月，在同卵双胞胎和异卵双胞胎中，记录的精神分裂症诊断同样常见。然而，精神分裂症的先证者一致率在同卵双胞胎（30.9%）中显著高于异卵双胞胎（6.5%）。合子性判定、诊断或确定中的偏差无法合理地解释这些结果。在登记处构建过程中对选择效应进行校正后，精神分裂症的一致率接近先前研究中的发现。根据登记处数据，遗传因素在精神分裂症病因学中的重要性至少与在包括糖尿病和高血压在内的几种常见医学病症中一样。NAS - NRC双胞胎登记处的结果支持遗传因素在精神分裂症病因学中的重要性。
