Ziemsen B, Agarwal D P, Hoo J J, Goedde H W
Arzneimittelforschung. 1983;33(11):1523-4.
The activity of phosphatidylethanolamine methyltransferase (PMT) in disrupted human erythrocytes and ghost cells was inhibited by lithium (Li+), imipramine and chlorpromazine. There was no inhibitory effect of the drugs in concentrations similar to the average therapeutic blood levels. Li+ exerted an inhibition on PMT activity in hemolysates at concentrations 8 times the average therapeutic level whereas chlorpromazine and imipramine showed an inhibitory effect on PMT in hemolysates at 10(3) fold their respective therapeutic serum level.
锂（Li+）、丙咪嗪和氯丙嗪可抑制人红细胞和空壳细胞中磷脂酰乙醇胺甲基转移酶（PMT）的活性。在与平均治疗血药浓度相似的浓度下，这些药物没有抑制作用。Li+在浓度为平均治疗水平8倍时对溶血产物中的PMT活性产生抑制作用，而氯丙嗪和丙咪嗪在其各自治疗血清水平的10³倍浓度下对溶血产物中的PMT显示出抑制作用。
