Nag M, Nandi N
Enzyme Chemistry Department, Indian Institute of Chemical Biology, Calcutta.
Biosci Rep. 1994 Jun;14(3):139-44. doi: 10.1007/BF01240246.
Psychoactive drugs like chlorpromazine (CPZ), imipramine, lithium and amphetamine in one way or another affect behaviour. The drug responses are presumably mediated by inducing a change in the activity of membrane bound enzymes. CPZ is very potent in inhibiting the alkaline phosphatase activity in rat brain. The combined effect of CPZ with other drugs shows that CPZ and imipramine together inhibit the enzyme activity significantly greater than the individual inhibition either by CPZ or by imipramine alone. Effective inhibition of the alkaline phosphatase activity with a single drug or combined drugs may lead to a change in neuronal permeability through glucocorticoids thereby affecting mood.
像氯丙嗪（CPZ）、丙咪嗪、锂盐和苯丙胺这样的精神活性药物会以某种方式影响行为。药物反应大概是通过诱导膜结合酶活性的变化来介导的。CPZ在抑制大鼠脑内碱性磷酸酶活性方面非常有效。CPZ与其他药物的联合作用表明，CPZ和丙咪嗪共同抑制酶活性的程度明显大于CPZ或丙咪嗪单独的抑制作用。用单一药物或联合药物有效抑制碱性磷酸酶活性可能会通过糖皮质激素导致神经元通透性的改变，从而影响情绪。
