Kohrman K A, Booman K A, Dorsky J, Rothenstein A S, Sedlak R I, Steltenkamp R J, Thompson G R
Food Chem Toxicol. 1983 Dec;21(6):741-4. doi: 10.1016/0278-6915(83)90206-5.
The potential of benzyl salicylate, an important fragrance and flavour ingredient, to induce hypersensitivity or to elicit reactions to pre-existing hypersensitivity in the general population was evaluated by analysing patch-test data. Results obtained from fragrance and formulator companies for a total of 10,538 patch tests on benzyl salicylate alone, on a variety of household and personal care consumer products and on fragrance blends containing benzyl salicylate were analysed as part of this survey. No induced or elicited responses directly attributable to benzyl salicylate were observed in the 35 patch tests on benzyl salicylate alone, or in the 10,503 patch tests on consumer products or fragrance blends containing benzyl salicylate. The highest concentration of benzyl salicylate tested in the consumer-product tests was 2 X 10(-1)%, and benzyl salicylate alone was tested at 10% in ethanol. This study indicates that benzyl salicylate has a very low potential to induce hypersensitivity ('induced' reactions) or to elicit reactions presumably attributable to pre-existing sensitization ('elicited' reactions) and thus supports the safe use of benzyl salicylate in consumer products and fragrance blends.
通过分析斑贴试验数据，评估了重要香料成分水杨酸苄酯在普通人群中诱发超敏反应或引发对已存在超敏反应的反应的可能性。作为本次调查的一部分，分析了香料公司和配方公司提供的总共10538次斑贴试验结果，这些试验分别针对单独的水杨酸苄酯、各种家用和个人护理消费品以及含有水杨酸苄酯的香料混合物。在仅针对水杨酸苄酯的35次斑贴试验中，以及在针对含有水杨酸苄酯的消费品或香料混合物的10503次斑贴试验中，均未观察到直接归因于水杨酸苄酯的诱发或激发反应。消费品试验中测试的水杨酸苄酯最高浓度为2×10（-1）%，水杨酸苄酯单独在乙醇中的测试浓度为10%。这项研究表明，水杨酸苄酯诱发超敏反应（“诱发”反应）或引发可能归因于预先存在的致敏作用的反应（“激发”反应）的可能性非常低，因此支持在消费品和香料混合物中安全使用水杨酸苄酯。
