Rothenstein A S, Booman K A, Dorsky J, Kohrman K A, Schwoeppe E A, Sedlak R I, Steltenkamp R J, Thompson G R
Food Chem Toxicol. 1983 Dec;21(6):727-33. doi: 10.1016/0278-6915(83)90204-1.
The potential of eugenol and of clove leaf oil, which contains a high concentration of eugenol, to induce delayed skin hypersensitivity or to elicit reactions due to pre-existing skin sensitization in man was evaluated by analysing patch-test data. Results from a total of 11,632 patch tests on eugenol itself, on various consumer products containing eugenol and/or clove leaf oil, and on fragrance blends containing eugenol and/or clove leaf oil were collected from fragrance and formulation companies. One instance of induced hypersensitivity and one instance of pre-existing sensitization were observed at eugenol patch-test concentrations of 5 X 10(-2) and 9 X 10(-2)% respectively. In both cases, subsequent patch testing showed skin responses to mixtures of eugenol and isoeugenol, but no further attempt was made to define the causative agent. The survey indicates that, at the concentrations present in consumer products, eugenol alone or as part of clove leaf oil has a very low potential either to elicit pre-existing sensitization ('elicited' reactions) or to induce hypersensitivity ('induced' reactions).
通过分析斑贴试验数据，评估了丁香酚以及含有高浓度丁香酚的丁香叶油在人体中诱发迟发性皮肤超敏反应或因既往皮肤致敏而引发反应的可能性。从香料和配方公司收集了总共11,632次斑贴试验的结果，这些试验分别针对丁香酚本身、含有丁香酚和/或丁香叶油的各种消费品以及含有丁香酚和/或丁香叶油的香料混合物。在丁香酚斑贴试验浓度分别为5×10⁻²%和9×10⁻²%时，观察到1例诱发的超敏反应和1例既往致敏情况。在这两种情况下，随后的斑贴试验显示皮肤对丁香酚和异丁香酚的混合物有反应，但未进一步尝试确定致病因子。该调查表明，在消费品中的浓度下，单独的丁香酚或作为丁香叶油的一部分，引发既往致敏（“激发”反应）或诱发超敏反应（“诱发”反应）的可能性非常低。
