对硝基苄基化合物的皮肤致敏潜力与化学反应性之间的相关性。
Correlations between skin sensitization potential and chemical reactivity for p-nitrobenzyl compounds.
作者信息
Roberts D W, Goodwin B F, Williams D L, Jones K, Johnson A W, Alderson J C
出版信息
Food Chem Toxicol. 1983 Dec;21(6):811-3. doi: 10.1016/0278-6915(83)90217-x.
PMID:6686587
Abstract
Quantitative relationships between skin sensitization potential and certain physico-chemical properties of alkylating agents have been reported. This study demonstrates the correlation of the relative alkylation index (RAI), derived from the alkylation rate and lipophilicity of an alkylating agent, with a set of experimental sensitization data obtained for a series of p-nitrobenzyl compounds.
摘要
已经报道了皮肤致敏潜力与烷基化剂的某些物理化学性质之间的定量关系。本研究证明了由烷基化剂的烷基化速率和亲脂性得出的相对烷基化指数（RAI）与一系列对硝基苄基化合物获得的一组实验致敏数据之间的相关性。
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