大脑组胺是否参与了镇痛药和氟哌啶醇的致僵作用？
Is the brain histamine involved in cataleptogenic action of analgesics and haloperidol?
作者信息
Malec D, Langwiński R
出版信息
Life Sci. 1983;33 Suppl 1:623-5. doi: 10.1016/0024-3205(83)90580-5.
PMID:6686640
Abstract
L-Histidine, histamine ivc, and amodiaquine (inhibitor of histamine catabolism) enhanced catalepsy induced by morphine, codeine and fentanyl. Haloperidol catalepsy was increased only by ivc histamine. H1 (but not H2) receptor antagonists have shown anticataleptic effect in the action of analgesics and haloperidol.
摘要
L-组氨酸、组胺静脉内注射以及阿莫地喹（组胺分解代谢抑制剂）增强了吗啡、可待因和芬太尼所致的僵住症。仅静脉内注射组胺可增强氟哌啶醇所致的僵住症。H1（而非H2）受体拮抗剂在镇痛药和氟哌啶醇的作用中显示出抗僵住症作用。
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