Broderick P A, Gardner E L, van Praag H M
Life Sci. 1983;33 Suppl 1:635-8. doi: 10.1016/0024-3205(83)90583-0.
The effect of the metabolically stable enkephalin pentapeptide analog, D-Ala2-D-Pro5-enkephalinamide monoacetate (DAP) (WY 42, 186) was studied on amphetamine-induced hyperactive behavior and on dopamine release from tuberculum olfactorium in male, Sprague-Dawley rats. The behavioral results showed that D-Ala2-D-Pro5-enkephalinamide monoacetate did not significantly alter hyperactivity, the mesolimbic component of amphetamine-induced stereotypy. In vivo electrochemical evidence, derived from catecholamine sensitive electrodes, showed that the D-Ala2-D-Pro5-enkephalinamide monoacetate did not significantly alter dopamine release from the tuberculum olfactorium, a mesolimbic terminal brain region. The similarity in the behavioral and biochemical responses of dopamine to the enkephalinamide analog suggests that the behavior and biochemistry may be subserved by similar underlying neural mechanisms.
研究了代谢稳定的脑啡肽五肽类似物D - Ala2 - D - Pro5 - 脑啡肽酰胺单乙酸盐（DAP）（WY 42,186）对雄性斯普拉格 - 道利大鼠中苯丙胺诱导的多动行为以及从嗅结节释放多巴胺的影响。行为学结果表明，D - Ala2 - D - Pro5 - 脑啡肽酰胺单乙酸盐不会显著改变多动行为，即苯丙胺诱导的刻板行为的中脑边缘成分。来自儿茶酚胺敏感电极的体内电化学证据表明，D - Ala2 - D - Pro5 - 脑啡肽酰胺单乙酸盐不会显著改变从嗅结节（一个中脑边缘终末脑区）释放多巴胺。多巴胺对脑啡肽酰胺类似物的行为和生化反应的相似性表明，行为和生物化学可能由相似的潜在神经机制支持。
