Carter C J, Pycock C J
Naunyn Schmiedebergs Arch Pharmacol. 1979 Jul;308(1):51-4. doi: 10.1007/BF00499718.
5,7-Dihydroxytryptamine lesions of the nucleus accumbens septi, or substantia nigra, resulted in a twofold increase in spontaneous locomotor activity. Striatal 5HT depletion also raised basal activity levels, as well as increasing rearing behaviour in an open field. The sterotyped responses to all doses of amphetamine tested (2.5--10 mg/kg, i.p.) were enhanced by lesions of the nucleus accumbens or substantia nigra. Striatal lesions only affected the response to the lowest dose of amphetamine. Lesions of the tuberculum olfactorium were without effect on spontaneous or amphetamine induced responses. The results support the concept of a modulatory 5HT influence on nigro-striatal function, and suggest that 5HT in the nucleus accumbens has an antagonistic role with respect to dopamine function in this site.
伏隔核或黑质的5,7-二羟基色胺损伤导致自发运动活动增加两倍。纹状体5-羟色胺耗竭也提高了基础活动水平，并增加了在旷场中的竖毛行为。伏隔核或黑质损伤增强了对所有测试剂量苯丙胺（2.5-10mg/kg，腹腔注射）的刻板反应。纹状体损伤仅影响对最低剂量苯丙胺的反应。嗅结节损伤对自发或苯丙胺诱导的反应没有影响。这些结果支持5-羟色胺对黑质-纹状体功能具有调节作用的概念，并表明伏隔核中的5-羟色胺在该部位对多巴胺功能具有拮抗作用。
