镉毒性：对鱼类血液和组织代谢物变化的诱导作用。

Cadmium toxicity: inducement of changes in blood and tissue metabolites in fish.

作者信息

Gill T S, Pant J C

出版信息

Toxicol Lett. 1983 Sep;18(3):195-200. doi: 10.1016/0378-4274(83)90093-0.

Abstract

The effects of acute (24 h) and chronic (90 days) cadmium (Cd) poisoning on blood and tissue metabolite levels of a teleost, Puntius conchonius were studied. Significant hyperglycemia with an increment in liver, kidney and ovary cholesterol occurred during acute Cd poisoning. By contrast, an enduring hypoglycemia and diminished levels of tissue cholesterol manifested the chronically intoxicated fish. Both acute and chronic Cd poisoning, however, caused marked hypocholesterolemia, glycogenolysis in liver and brain, and a concomitant rise in myocardium glycogen concentration. Testes cholesterol was found to be depleted after both acute and chronic (60 days) Cd poisoning.

摘要

研究了急性（24小时）和慢性（90天）镉（Cd）中毒对一种硬骨鱼——五须鲃血液和组织代谢物水平的影响。急性镉中毒期间出现显著的高血糖，同时肝脏、肾脏和卵巢中的胆固醇增加。相比之下，长期中毒的鱼表现为持续性低血糖和组织胆固醇水平降低。然而，急性和慢性镉中毒均导致明显的低胆固醇血症、肝脏和大脑中的糖原分解，同时心肌糖原浓度升高。急性和慢性（60天）镉中毒后，睾丸中的胆固醇均减少。