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[大鼠神经元对固定化情绪应激的化学敏感性]

[Chemical sensitivity of neurons to immobilization emotional stress in the rat].

作者信息

Iumatov E A, Kiiatkin E A

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 1983 Nov-Dec;33(6):1128-34.

PMID:6686743
Abstract

Chemical sensitivity of the neurones of the medial thalamus (MT) and ventromedial hypothalamus (VMH) to noradrenaline (NA) was studied microionophoretically in conditions of 30-hour immobilization of rats. Chemical sensitivity of single neurons of MT as well as VMH during immobilization is characterized by a certain instability, showed in changes of their reactions at repeated NA applications. These changes were observed significantly more frequently in MT neurones especially at the initial stage of immobilization. At the final stage as well as in unrestrained control animals, changes of the sensitivity were seen significantly more seldom. At the initial stage of rats' immobilization a significant increase of the number of MT and VMH cells responding to NA application by the excitative type of reactions was also observed.

摘要

在大鼠30小时制动的条件下,采用微量离子电泳法研究了丘脑内侧(MT)和下丘脑腹内侧(VMH)神经元对去甲肾上腺素(NA)的化学敏感性。制动期间MT以及VMH单个神经元的化学敏感性具有一定的不稳定性,表现为在重复施加NA时其反应发生变化。这些变化在MT神经元中观察到的频率明显更高,尤其是在制动初期。在末期以及未受约束的对照动物中,敏感性变化明显少见得多。在大鼠制动初期,还观察到MT和VMH中对NA施加产生兴奋性反应类型的细胞数量显著增加。

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