Brandstätter G, Kratochvil P, Stupnicki T, Zenker G
Arzneimittelforschung. 1983;33(12):1691-3.
The effect of a new anticholinergic drug, ciclotropium bromide, on artificially induced pressure elevations in the common bile duct is reported. The endoscopic manometry allows a precise pressure measurement in the biliary system. For the artificial pressure elevation an X-ray contrast medium was injected into the common bile duct until the pain threshold was reached. In each patient a statistically significant pressure reduction accompanied by pain relief was reached. The method used shows the drug effects by objective measurement of the pressure reduction and the subjective indication of the pain relief.
据报道，一种新型抗胆碱能药物——溴环扁吡酯，对人工诱导的胆总管压力升高有影响。内镜测压法可精确测量胆道系统的压力。为了人工升高压力，将X射线造影剂注入胆总管，直至达到疼痛阈值。在每位患者中，均实现了具有统计学意义的压力降低，并伴有疼痛缓解。所采用的方法通过客观测量压力降低以及主观表明疼痛缓解来显示药物效果。
