Brandstätter G
Z Gastroenterol. 1983 Apr;21(4):168-74.
The effects of pharmaca on artificially elevated pressures in the common bile duct are reported. The measurements were performed using a catheter for pressure measurements, which was introduced with an endoscope via the papilla of Vater into the common bile duct. For the artificial pressure elevation an x-ray contrast medium was instilled into the common bile duct until the pain threshold was reached. Nitroglycerin most effectively reduced the elevated pressures (to 52.1 +/- 12.4%) of the initial value). A weaker effect was produced by Novalgin (74.7 +/- 15.6%) and Buscopan (69.7 +/- 29.1%). With Euphyllin only a small pressure reduction could be observed (86.1 +/- 15.4%). Pain relief in each patient could only be effected with nitroglycerin. The method used makes it possible to estimate the effects of pharmaca on the artificially elevated pressure of the common bile duct objectively by measuring the pressure reduction, and subjectively by registering the diminution of the pain sensation.
报道了药物对胆总管人工升高压力的影响。测量使用用于压力测量的导管进行，该导管通过内窥镜经十二指肠乳头插入胆总管。为了人工升高压力，将X射线造影剂注入胆总管直至达到疼痛阈值。硝酸甘油最有效地降低了升高的压力（降至初始值的52.1±12.4%）。诺瓦经（74.7±15.6%）和解痉灵（69.7±29.1%）的效果较弱。使用氨茶碱仅观察到小幅度的压力降低（86.1±15.4%）。仅硝酸甘油能使每位患者的疼痛缓解。所使用的方法使得通过测量压力降低客观地估计药物对胆总管人工升高压力的影响，并通过记录疼痛感觉的减轻主观地进行估计成为可能。
