Kohonen A, Palmgren O, Renkonen O V
Int J Pediatr Otorhinolaryngol. 1983 Sep;6(1):89-94. doi: 10.1016/s0165-5876(83)80107-4.
Thirty-nine middle ear fluid samples from 23 patients with chronic secretory otitis media were studied. The patients received 3 doses of 3 mg of trimethoprim and 5 mg of sulfadiazine per kg body weight before tympanostomy, the last dose being given 80-270 min (mean 142 min) prior to operation. Mean trimethoprim concentrations were 1.62 micrograms/ml (range 0.8-3.5) and mean sulfadiazine concentrations 10.54 micrograms/ml (range 0-25.0). For most patients the levels exceeded the usual MIC-values for the two commonest pathogens; pneumococci and Haemophilus influenzae. Otitis media caused by beta-lactamase producing Haemophilus is an important indication for trimethoprim-sulfonamide therapy.
