Nelson J D, Ginsburg C M, Mcleland O, Clahsen J, Culbertson M C, Carder H
Int J Pediatr Otorhinolaryngol. 1981 Dec;3(4):327-34. doi: 10.1016/0165-5876(81)90057-4.
Antibiotics concentrations in middle ear fluid (MEF), saliva and tears were measured in children with persistent middle ear effusions undergoing tympanostomy tube placement. In 31 children given cefaclor, specimens of serum, saliva and MEF were collected at 0.5, 1, 2, 3 or 5 h after a dose. Another group of 37 children were randomized to receive a single dose of penicillin V, amoxicillin, ampicillin, erythromycin estolate, erythromycin ethylsuccinate, trimethoprim-sulfamethoxazole or cefaclor. Concentrations of antibiotics in saliva and tears bore no consistent relationship to those in MEF. Mean concentrations of all drugs in MEF were several-fold greater than the usual minimal inhibitory concentrations (MIC) of pneumococci, but only with trimethoprim and cefaclor were they greater than in usual MIC's for Haemophilus influenzae. Concentrations of antibiotics in MEF in persistent effusions were comparable to those previously reported in acute purulent effusions.
对接受鼓膜置管术的持续性中耳积液患儿的中耳液（MEF）、唾液和泪液中的抗生素浓度进行了测量。在31名服用头孢克洛的儿童中，给药后0.5、1、2、3或5小时采集血清、唾液和MEF样本。另一组37名儿童被随机分配接受单剂量的青霉素V、阿莫西林、氨苄西林、无味红霉素、琥乙红霉素、甲氧苄啶-磺胺甲恶唑或头孢克洛。唾液和泪液中的抗生素浓度与中耳液中的抗生素浓度没有一致的关系。中耳液中所有药物的平均浓度比肺炎球菌通常的最小抑菌浓度（MIC）高几倍，但只有甲氧苄啶和头孢克洛的浓度高于流感嗜血杆菌的通常MIC。持续性积液中中耳液中的抗生素浓度与先前报道的急性化脓性积液中的浓度相当。
