降钙素对老年大鼠大脑的影响。

Effects of calcitonin on the brain of aged rats.

作者信息

Clementi G, Prato A, Bernardini R, Nicoletti F, Patti F, De Simone D, Scapagnini U

出版信息

Neurobiol Aging. 1983 Fall;4(3):229-32. doi: 10.1016/0197-4580(83)90025-8.

Abstract

We have recently demonstrated that calcitonin, a putative neuromodulator, may influence extrapyramidal motor system by decreasing nigro-striatal dopaminergic function. Since calcitonin is extensively used in aged patients, we have investigated whether calcitonin might influence extrapyramidal motor behavior (haloperidol-induced catalepsy and apomorphine-induced hyperactivity) in rats of different ages. Intracerebroventricular injection of salmon calcitonin (1 micrograms/kg) prevented apomorphine-induced hyperactivity in 2, 7, 18 or 21 month old rats, but potentiated haloperidol-induced catalepsy only in 2 or 7 month old rats. In addition, in all the animals salmon calcitonin significantly decreased the secretion of prolactin, an anterior pituitary hormone that may act at central level enhancing nigro-striatal dopaminergic activity.

摘要

我们最近证明，降钙素作为一种假定的神经调节剂，可能通过降低黑质-纹状体多巴胺能功能来影响锥体外系运动系统。由于降钙素在老年患者中广泛使用，我们研究了降钙素是否会影响不同年龄大鼠的锥体外系运动行为（氟哌啶醇诱导的僵住症和阿扑吗啡诱导的多动）。脑室内注射鲑鱼降钙素（1微克/千克）可预防2、7、18或21月龄大鼠阿扑吗啡诱导的多动，但仅在2或7月龄大鼠中增强氟哌啶醇诱导的僵住症。此外，在所有动物中，鲑鱼降钙素均显著降低催乳素的分泌，催乳素是一种垂体前叶激素，可能在中枢水平起作用增强黑质-纹状体多巴胺能活性。