Reggio A, Condorelli D F, De Simone D, Giammona G, Maccagnano C, Panico A M, Tigano G
Boll Soc Ital Biol Sper. 1981 Aug 30;57(16):1655-9.
The effect of endogenous hyperprolactinemia induced by pituitary transplantation under the kidney capsule on haloperidol induced catalepsy was evaluated in male Wistar rats treated with two doses of the drug (500 gamma/kg; 2 mg/kg i.p.). Rats of 220 +/- 30 g received intraperitoneal injection of haloperidol. Every five minutes following drug administration the rats were assessed for catalepsy by placing the forepaw on a horizontal bar, and observed for two minutes. Data obtained show that hyperprolactinemia potentiates the cataleptic score in rats treated with dose of 500 gamma/kg i.p., while no significant difference was observed between hyperprolactinemic rats and control rats, at the dose of 2 mg/kg i.p. of haloperidol.
在接受两剂药物（500微克/千克；2毫克/千克腹腔注射）治疗的雄性Wistar大鼠中，评估了肾包膜下垂体移植诱导的内源性高催乳素血症对氟哌啶醇诱导的僵住症的影响。体重220±30克的大鼠接受氟哌啶醇腹腔注射。给药后每隔五分钟，将大鼠的前爪放在水平杆上评估僵住症，并观察两分钟。获得的数据表明，高催乳素血症增强了腹腔注射500微克/千克剂量药物的大鼠的僵住症评分，而在腹腔注射2毫克/千克剂量氟哌啶醇时，高催乳素血症大鼠与对照大鼠之间未观察到显著差异。
