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[血液和组织因子对培养的小牛主动脉内皮细胞迁移的影响]

[Effect of blood and tissue factors on the migration of cultured endothelial cells of calf aorta].

作者信息

Teuscher E, Jakob W, Zöllner R, Heder G, Pilgrim H, Halle W

出版信息

Biomed Biochim Acta. 1983;42(9):1157-64.

PMID:6686933
Abstract

Fractions of extracts of porcine corpora lutea, of bovine brain with fibroblast growth factor activity and whole blood serum versus plasma derived serum were tested using Boyden technique and agarose migration with regard to their influence on the migration behaviour of endothelial cells of calf aortas. All factors showed a concentration dependent stimulation of random migration of the cells. Only whole blood serum versus plasma derived serum had chemotactic activity. Thus it must be supposed that vascularization processes will be only favoured by the first mentioned two factors whereas angiogenesis will be possibly triggered by factors released from blood platelets during blood coagulation.

摘要

采用博伊登技术和琼脂糖迁移法,测试了猪黄体提取物、具有成纤维细胞生长因子活性的牛脑提取物以及全血血清与血浆衍生血清对小牛主动脉内皮细胞迁移行为的影响。所有因素均显示出对细胞随机迁移的浓度依赖性刺激。只有全血血清与血浆衍生血清具有趋化活性。因此,可以推测上述前两个因素仅有利于血管形成过程,而血管生成可能是由血液凝固过程中血小板释放的因子触发的。

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[Effect of blood and tissue factors on the migration of cultured endothelial cells of calf aorta].[血液和组织因子对培养的小牛主动脉内皮细胞迁移的影响]
Biomed Biochim Acta. 1983;42(9):1157-64.
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