[Effect of blood and tissue factors on the migration of cultured endothelial cells of calf aorta].

Fractions of extracts of porcine corpora lutea, of bovine brain with fibroblast growth factor activity and whole blood serum versus plasma derived serum were tested using Boyden technique and agarose migration with regard to their influence on the migration behaviour of endothelial cells of calf aortas. All factors showed a concentration dependent stimulation of random migration of the cells. Only whole blood serum versus plasma derived serum had chemotactic activity. Thus it must be supposed that vascularization processes will be only favoured by the first mentioned two factors whereas angiogenesis will be possibly triggered by factors released from blood platelets during blood coagulation.