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Inhibitory effects on lipid metabolism in cultured cells of ML-236B, a potent inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme-A reductase.

作者信息

Kaneko I, Hazama-Shimada Y, Endo A

出版信息

Eur J Biochem. 1978 Jun 15;87(2):313-21. doi: 10.1111/j.1432-1033.1978.tb12380.x.

DOI:10.1111/j.1432-1033.1978.tb12380.x
PMID:668696
Abstract
摘要

相似文献

1
Inhibitory effects on lipid metabolism in cultured cells of ML-236B, a potent inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme-A reductase.3-羟基-3-甲基戊二酰辅酶A还原酶的强效抑制剂ML-236B对培养细胞脂质代谢的抑制作用。
Eur J Biochem. 1978 Jun 15;87(2):313-21. doi: 10.1111/j.1432-1033.1978.tb12380.x.
2
Tissue-selective inhibition of cholesterol synthesis in vivo by pravastatin sodium, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor.普伐他汀钠（一种3-羟基-3-甲基戊二酰辅酶A还原酶抑制剂）对体内胆固醇合成的组织选择性抑制作用。
Biochim Biophys Acta. 1990 Jul 16;1045(2):115-20. doi: 10.1016/0005-2760(90)90139-o.
3
Lack of correlation between the rate of cholesterol biosynthesis and the activity of 3-hydroxy-3-methylgutaryl coenzyme A reductase in rats and in fibroblasts treated with ML-236B.
Biochem Biophys Res Commun. 1978 May 15;82(1):247-54. doi: 10.1016/0006-291x(78)90602-2.
4
Inhibition of cholesterol synthesis in vitro and in vivo by ML-236A and ML-236B, competitive inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
Eur J Biochem. 1977 Jul 1;77(1):31-6. doi: 10.1111/j.1432-1033.1977.tb11637.x.
5
A possible translational control of 3-hydroxy-3-methylglutaryl coenzyme A reductase induction by ML-236b(compactin) in isolated rat hepatocytes.
Biochem Biophys Res Commun. 1982 Sep 16;108(1):240-6. doi: 10.1016/0006-291x(82)91857-5.
6
Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase.在用还原酶的竞争性抑制剂美伐他汀（ML - 236B）孵育的人成纤维细胞中3 - 羟基 - 3 - 甲基戊二酰辅酶A还原酶活性的诱导。
J Biol Chem. 1978 Feb 25;253(4):1121-8.
7
The regulation of ubiquinone synthesis in fibroblasts: the effect of modulators of beta-hydroxy-beta-methylglutaryl-coenzyme A reductase activity.成纤维细胞中泛醌合成的调节：β-羟基-β-甲基戊二酰辅酶A还原酶活性调节剂的作用。
Arch Biochem Biophys. 1981 Sep;210(2):592-7. doi: 10.1016/0003-9861(81)90225-3.
8
Overaccumulation of 3-hydroxy-3-methylglutaryl-coenzyme-A reductase in a compactin(ML-236B)-resistant mouse cell line with defects in the regulation of its activity.在一株对美伐他汀（ML-236B）耐药且其活性调节存在缺陷的小鼠细胞系中，3-羟基-3-甲基戊二酰辅酶A还原酶过度积累。
Eur J Biochem. 1987 May 4;164(3):547-52. doi: 10.1111/j.1432-1033.1987.tb11161.x.
9
Effects of cholesterol sulfate on lipid metabolism in cultured human keratinocytes and fibroblasts.胆固醇硫酸酯对培养的人角质形成细胞和成纤维细胞脂质代谢的影响。
J Lipid Res. 1987 Aug;28(8):955-67.
10
Specific inhibition of desmosterol synthesis by ML--236B in mouse LM cells grown in suspension in a lipid-free medium.
Jpn J Med Sci Biol. 1978 Jun;31(3):225-33. doi: 10.7883/yoken1952.31.225.

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