Desikan K V, Mukherjee A, Ramu G, Tiwari V D
Int J Lepr Other Mycobact Dis. 1983 Dec;51(4):473-80.
Skin testing with Dharmendra antigen was performed on 55 patients with TT, BT, BL, and LL types of leprosy and the reaction measured at different intervals from 24 hr to 28 days. At various time intervals, a biopsy specimen was taken from the reaction site. In TT and BT cases, the erythema was maximum at 48 hr; while the induration was maximum at 21 days. The sequence of the histological changes was built up on the observations made from different cases at varying intervals. The quantum of cellular exudate was high in TT and BT cases as compared to BL and LL cases. The cellular distribution showed loose scattering of cells in the LL and BL types and attempts to form tight clusters in the TT and BT cases. Neutrophils were predominant during the first 48 hr, particularly in the LL, BL, and BT types. By 72 hr the cells were mainly lymphocytic. A tendency for the lymphocytes to cluster around nerve twigs was seen in the TT and BT cases. In the early reaction the quantum of exudate correlated both with erythema and induration; while in the late reaction, it correlated with induration only. The intensity of the early lepromin reaction was more in BT than in TT leprosy, while the induration in the late reaction was more in TT than in BT types. The significance of these findings is discussed.
对55例结核样型（TT）、界线类偏结核样型（BT）、界线类偏瘤型（BL）和瘤型（LL）麻风患者进行了用达门德拉抗原的皮肤试验，并在24小时至28天的不同间隔测量反应。在不同时间间隔，从反应部位取活检标本。在TT和BT病例中，红斑在48小时时最大；而硬结在21天时最大。组织学变化的顺序是基于对不同病例在不同间隔的观察建立起来的。与BL和LL病例相比，TT和BT病例中的细胞渗出量较高。细胞分布显示在LL和BL型中细胞呈松散散布，而在TT和BT病例中细胞试图形成紧密聚集。在最初48小时内中性粒细胞占主导，特别是在LL、BL和BT型中。到72小时时，细胞主要是淋巴细胞。在TT和BT病例中可见淋巴细胞有围绕神经小枝聚集的趋势。在早期反应中，渗出量与红斑和硬结均相关；而在晚期反应中，它仅与硬结相关。早期麻风菌素反应的强度在BT麻风中比在TT麻风中更大，而晚期反应中的硬结在TT中比在BT型中更大。讨论了这些发现的意义。
