Summers M P, Enever R P, Carless J E
J Pharm Pharmacol. 1976 Feb;28(2):89-99. doi: 10.1111/j.2042-7158.1976.tb04105.x.
Various crystal forms of sulphathiazole, barbitone and aspirin were compressed in a single-punch tablet machine instrumented to monitor axially applied and radially transmitted forces, and upper punch movement. The changes in radial stress during the compression cycle depended upon the polymorphic form of the compressed material. The results were rationalized in terms of the degree of plastic flow/crushing that occurred with each material, and the degree to which the final compact underwent elastic compression. It is postulated that the reduction in the transition temperature of polymorphic forms of sulphathiazole and barbitone and the polymorphic transition of sulphathiazole Form II was due to the production of dislocations in the crystal and the crystals at crystal boundaries formed in the compressed materials.
在一台配备监测轴向施加力、径向传递力及上冲头运动装置的单冲压片机中，对磺胺噻唑、巴比妥和阿司匹林的各种晶型进行压制。压制循环过程中径向应力的变化取决于被压制材料的多晶型形式。根据每种材料发生的塑性流动/破碎程度以及最终压块发生弹性压缩的程度，对结果进行了合理分析。据推测，磺胺噻唑和巴比妥多晶型形式的转变温度降低以及磺胺噻唑II型的多晶型转变是由于晶体中产生了位错以及在压制材料中晶界处形成了晶体。
