Kellermann K
Eur J Pediatr. 1978 Jul 3;128(3):207-12. doi: 10.1007/BF00444306.
We present a six years follow up of a 6 1/2 year-old boy with recurrent aphasia, sporadic emotional regression and a convulsive disorder. The electroencephalogram reading during sleep showed continuous, generalized, hypersynchronous activity without clinical evidence of seizure ("subclinical bioelectric status epilepticus"). Clinical, laboratory and instrumental data revealed no evidence of a morphological lesion of the brain, either space-occupying, inflammatory, degenerative, or autoimmune. Remissions occured with and without anticonvulsant and steroid therapy. The hypothetical location, type, and etiology of the process are discussed. The syndrome appears to represent a functional disorganisation of speech-controlling areas of the brain.
我们报告了一名6岁半男孩的6年随访情况，该男孩患有复发性失语症、偶发性情感退化和惊厥性疾病。睡眠期间的脑电图显示为持续的、全身性的、高度同步的活动，无癫痫发作的临床证据（“亚临床生物电癫痫状态”）。临床、实验室和影像学检查数据均未发现脑形态学病变的证据，无论是占位性、炎症性、退行性还是自身免疫性病变。在使用和未使用抗惊厥药物及类固醇治疗的情况下均出现了缓解。文中讨论了该病症可能的发病部位、类型及病因。该综合征似乎代表了大脑语言控制区域的功能紊乱。
