Matsuda H, Tanaka H, Nogami S, Muto M
Jpn J Exp Med. 1983 Dec;53(6):271-4.
The mode of action of praziquantel on Schistosoma japonicum eggs was examined in mice and in vitro. In a long term oogram observation of mouse intestine, lasting from 1 to 56 days after oral administration of 100 mg/kg 4 times in one day, many empty egg shells were observed from the next day. Immature eggs, however, were not killed, but developed into miracidia that later degenerated into granulated and calcified eggs. In the oograms of mouse, from 5 to 240 minutes after a single oral dose of 100 mg/kg of praziquantel, miracidium hatching occurred 5 minutes in the tissues after treatment. In the in vitro experiment, miracidia in eggs from cut pieces of intestine began to hatch starting 5 minutes after exposure to praziquantel at least at a concentration of 1 ng/ml and reached maximum hatching at 30 minutes and died in several minutes after hatching.
在小鼠体内和体外研究了吡喹酮对日本血吸虫卵的作用方式。在对小鼠肠道进行的长达1至56天的长期虫卵观察中，一天内4次口服100mg/kg后，从第二天起观察到许多空卵壳。然而，未成熟的卵并未被杀死，而是发育成毛蚴，随后退化为颗粒状和钙化的卵。在小鼠的虫卵观察中，单次口服100mg/kg吡喹酮后5至240分钟，治疗后5分钟组织中的毛蚴开始孵化。在体外实验中，肠道切片卵中的毛蚴在暴露于至少1ng/ml浓度的吡喹酮后5分钟开始孵化，30分钟时孵化率达到最高，孵化后几分钟内死亡。
