Jiangsu Institute of Parasitic Diseases, 117 Yangxiang, Meiyuan, Wuxi 214064, People's Republic of China.
Parasitol Res. 2011 Dec;109(6):1501-7. doi: 10.1007/s00436-011-2670-3. Epub 2011 Oct 8.
Praziquantel, due to high efficacy, excellent tolerability, few and transient side effects, simple administration, and competitive cost, is virtually the only drug of choice for treatment of human schistosomiasis. Treatment of schistosomiasis has shown great advances with the introduction of the drug into the therapeutic arsenal in areas that are endemic for the parasite. However, the drug presents various efficacies against different developmental stages of schistosomes, appearing an oddity intermitted mode. The present review article reviews the effects and mechanism of action of praziquantel against schistosomes briefly and suggests the research on this oddity phenomenon.
吡喹酮由于疗效高、耐受性好、副作用少且短暂、给药简单、价格低廉，几乎是治疗人类血吸虫病的唯一首选药物。在寄生虫流行地区，将该药物引入治疗方案后，血吸虫病的治疗取得了巨大进展。然而，该药物对不同发育阶段的血吸虫具有不同的疗效，呈现出间歇性奇异模式。本文简要综述了吡喹酮对血吸虫的作用和作用机制，并对这一奇异现象的研究提出了建议。
