对早产儿从出生到孕龄足月时血清维生素 D 结合蛋白的系列分析。

Serial analyses of serum vitamin D-binding protein in preterm infants from birth to postconceptual maturity.

作者信息

Hillman L S, Haddad J G

出版信息

J Clin Endocrinol Metab. 1983 Jan;56(1):189-91. doi: 10.1210/jcem-56-1-189.

Abstract

Serial measurements of vitamin D-binding protein (DBP) were made in 28 infants of 29.7 +/- 2 weeks gestation and 1162 +/- 344 g birthweight. Mean (+/- SD) values (micrograms per ml) were: cord, 375 +/- 97; 1 week, 396 +/- 82; 3 weeks, 382 +/- 67; 6 weeks, 393 +/- 78; 9 weeks, 372 +/- 120; and 12 weeks, 490 +/- 130. At 12 weeks of age (40-42 weeks postconceptual age), DBP, 25-hydroxyvitamin D (25OHD), calcium, phosphorus, copper, and albumin were all significantly increased (by paired t test). At this point, but not earlier, DBP was correlated with 25OHD (r = 0.69; P less than 0.01) and phosphorus (r = 0.49; P less than 0.05), and 25OHD was correlated with phosphorus (r = 0.48; P less than 0.05) and calcium (r = 0.44; P less than 0.05). This may represent a concomitant maturation of the liver's protein synthetic abilities and the absorption and/or 25-hydroxylation in the liver of the parent vitamin D.

摘要

对28名孕龄29.7±2周、出生体重1162±344克的婴儿进行了维生素D结合蛋白（DBP）的系列测量。平均（±标准差）值（微克/毫升）如下：脐带血，375±97；1周时，396±82；3周时，382±67；6周时，393±78；9周时，372±120；12周时，490±130。在12周龄（孕龄40 - 42周）时，DBP、25 - 羟维生素D（25OHD）、钙、磷、铜和白蛋白均显著升高（配对t检验）。此时而非更早时候，DBP与25OHD相关（r = 0.69；P＜0.01）以及与磷相关（r = 0.49；P＜0.05），并且25OHD与磷相关（r = 0.48；P＜0.05）以及与钙相关（r = 0.44；P＜0.05）。这可能代表肝脏蛋白质合成能力以及母体维生素D在肝脏中的吸收和/或25 - 羟化作用同时成熟。