Takahashi T, Wagenvoort C A
Arch Pathol Lab Med. 1983 Jan;107(1):23-8.
Pulmonary arteries were counted per surface area of lung sections, with a correction for the degree of lung collapse, in 31 subjects who had congenital cardiac defects and pulmonary hypertension. Arterial diameters were also established, as were the degrees of any pulmonary vascular lesions. In comparison with control cases, the density of the smallest muscularized arterioles was significantly increased in those subjects without advanced pulmonary vascular disease. With increasing intimal fibrosis, the number of small arteries decreased. In the presence of severe alterations (eg, plexiform lesions), the numbers were distinctly reduced. The density of arteries larger than 100 micrometer in diameter was hardly affected, independent of the severity of vascular changes. Our results indicate that congenital underdevelopment of the pulmonary arterial tree is uncommon and certainly not the rule in cases of congenital cardiac defects.
在31例患有先天性心脏缺陷和肺动脉高压的受试者中，根据肺切片的表面积计算肺动脉数量，并对肺萎陷程度进行校正。还确定了动脉直径以及任何肺血管病变的程度。与对照病例相比，在没有晚期肺血管疾病的受试者中，最小的肌化小动脉密度显著增加。随着内膜纤维化的增加，小动脉数量减少。在存在严重改变（如丛状病变）的情况下，数量明显减少。直径大于100微米的动脉密度几乎不受影响，与血管变化的严重程度无关。我们的结果表明，肺动脉树先天性发育不全并不常见，在先天性心脏缺陷病例中肯定不是普遍规律。
