Takahashi T, Wagenvoort N, Wagenvoort C A
Arch Pathol Lab Med. 1983 Jan;107(1):19-22.
In a series of 24 subjects who ranged in age from 2.5 months to 50 years and who were not suffering from cardiac or pulmonary disease, the density of muscularized pulmonary arteries was established in relation to their diameter. The number of arteries per unit area of lung tissue was corrected to account for various states of lung expansion of or collapse. The density of pulmonary arteries decreased rapidly during the first few years of life, then more gradually during the first two decades of life. Concomitantly, the diameter of the smallest muscularized arterial branches increased with age. These findings indicate that, even after completed development of lung tissue, there is a retraction of media in the sense that small arterioles lose their media, a process that continues until early adulthood. The values thus obtained may serve as a standard for comparison when the pulmonary arterial density is studied in cases of pulmonary hypertension in which it reportedly is greatly diminished.
在一组年龄从2.5个月至50岁、未患心脏或肺部疾病的24名受试者中，确定了肌化肺动脉的密度与其直径的关系。对肺组织单位面积内的动脉数量进行了校正，以考虑肺膨胀或萎陷的各种状态。肺动脉密度在生命的最初几年迅速下降，然后在生命的前二十年下降得较为缓慢。与此同时，最小的肌化动脉分支的直径随年龄增加。这些发现表明，即使在肺组织完全发育后，从小动脉失去其介质的意义上来说，仍存在中膜退缩，这一过程一直持续到成年早期。当在据报道肺动脉密度大大降低的肺动脉高压病例中研究肺动脉密度时，由此获得的值可作为比较的标准。
