Shah V P, Prasad V K, Alston T, Cabana B E, Gural R P, Meyer M C
J Pharm Sci. 1983 Mar;72(3):306-8. doi: 10.1002/jps.2600720325.
Dissolution profiles for 11 brands of phenytoin sodium capsules were carried out by the basket and paddle methods (USP) and the spin-filter method. The results from the dissolution studies have been correlated with observed differences in in vivo parameters (Cmax and tmax). The dissolution by the basket method at 50 rpm in water gave a correlation greater than 0.9. The results suggest the existence of two types of phenytoin sodium products on the market.
采用篮法、桨法（美国药典）和旋转过滤法对11个品牌的苯妥英钠胶囊进行了溶出度研究。溶出度研究结果与观察到的体内参数（Cmax和tmax）差异相关。在水中以50转/分钟的转速采用篮法进行溶出时，相关性大于0.9。结果表明市场上存在两种类型的苯妥英钠产品。
