Prediction of multiple-dose blood level curves of drugs with rapid changes in doses and/or dosing intervals.
作者信息
Ng P K, Collins-Nakai R L
出版信息
Int J Biomed Comput. 1983 Jul;14(4):275-86. doi: 10.1016/0020-7101(83)90002-8.
PMID:6688606
Abstract
This paper describes a program which can predict multiple-dose blood level curves of any drug administered orally or intravenously with up to a maximum of three changes in the dosage regimen at any time during the treatment period. This program is applicable to any drug in a given individual provided that the single-dose blood level curve equation (in the form of a two-exponential function) of the first or the last dose of the therapy in this individual is known.
摘要
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