Hammer R, Bozler G, Heinzel G, Koss F W
Arzneimittelforschung. 1977;27(4a):928-31.
An equation is given to describe the plasma level curve of any linear compartment model following multiple dosing of various doses after various time intervals. The equation is especially suitable to be used with desk top computers equipped with a plotting device. A dosage regimen can be simulated using the parameters derived from single dose experiments. Experimental check-up of the predicted curves is necessary and illustrated by two examples. Systematic deviations from the prediction indicate changes in the biological system, e.g., in absorption, by enzyme induction, saturable processes, etc.
给出了一个方程，用于描述在不同时间间隔给予不同剂量的多次给药后，任何线性房室模型的血浆水平曲线。该方程特别适用于配备绘图设备的台式计算机。可以使用从单剂量实验得出的参数来模拟给药方案。对预测曲线进行实验验证是必要的，并通过两个例子进行说明。与预测的系统性偏差表明生物系统发生了变化，例如吸收方面的变化，可能是由于酶诱导、饱和过程等原因。
