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A calculator program to determine k and V from measured serum drug concentrations by a two point curve fitting method.

作者信息

Jones E M

出版信息

Int J Biomed Comput. 1982 Sep;13(5):387-402. doi: 10.1016/0020-7101(82)90004-6.

DOI:10.1016/0020-7101(82)90004-6
PMID:6897058
Abstract

A calculator program is presented which determines k and V from two drugs levels or k from an assumed V and one drug level during maintenance dosing with any of four dosing schedules: intermittent, fixed interval; intermittent, two fixed intervals; intermittent, non-uniform dose, non-uniform interval; continuous intravenous infusion/sustained release. A loading dose and or one additional level taken before maintenance dosing begins can be taken into account for additional flexibility. Steady state concentrations are projected when dosage regimen and pharmacokinetic parameters are known.

摘要

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