Nitroreduction of benznidazole and nifurtimox by rat and human feces.
作者信息
de Toranzo E G, Masana M, Castro J A
出版信息
Res Commun Chem Pathol Pharmacol. 1983 Aug;41(2):341-4.
PMID:6688884
Abstract
Rat and human feces are able to reduce nitro group from Benznidazole (N-benzyl-2-nitro-1-imidazole acetamide) and Nifurtimox (4[5-nitrofurfurylidene)-amino)-3-methylthiomorpholine-1,1-dioxide), two chemotherapeutic agents against Chagas' disease. Feces from rats treated with neomycin sulfate lack nitroreductase activity evidencing the bacterial origin of the enzyme.
摘要
Zotero 插件