de Toranzo E G, Masana M, Castro J A
Res Commun Chem Pathol Pharmacol. 1983 Aug;41(2):341-4.
Rat and human feces are able to reduce nitro group from Benznidazole (N-benzyl-2-nitro-1-imidazole acetamide) and Nifurtimox (4[5-nitrofurfurylidene)-amino)-3-methylthiomorpholine-1,1-dioxide), two chemotherapeutic agents against Chagas' disease. Feces from rats treated with neomycin sulfate lack nitroreductase activity evidencing the bacterial origin of the enzyme.
大鼠和人类粪便能够还原两种治疗恰加斯病的化疗药物——苯硝唑（N-苄基-2-硝基-1-咪唑乙酰胺）和硝呋替莫（4-[5-硝基糠叉基）-氨基]-3-甲基硫代吗啉-1,1-二氧化物）中的硝基。用硫酸新霉素处理过的大鼠粪便缺乏硝基还原酶活性，这证明了该酶的细菌来源。
