[Serum gastrin levels before and after short-term treatment of duodenal ulcer with cimetidine and pirenzepin].

Serum gastrin was studied before meals in 71 patients with duodenal ulcer, treated with various doses of simetidin and pyrensepin. Gastrin level was elevated after a treatment with 1 g simetidin daily and 125 mg pyrensepin, and remained unchanged with pyrensepin treatment (50 and 100 mg daily). A tendency to decreased gastrin level was observed after the treatment with simetidin 400 mg daily. Under those circumstances the attempt at duodenal ulcer treatment with lower simetidin doses, than the usual, is justified.