Dal Monte P R, D'Imperio M, Ferri M, Fratucello F, del Soldato P
Hepatogastroenterology. 1985 Jun;32(3):126-8.
Treatment of peptic ulcer in "non-responders" with the combination of pirenzepine and cimetidine was evaluated in a longterm study. Patients who did not respond to two months of treatment, first with cimetidine (1 g/day), and then pirenzepine (150 mg/day), were given one of these two compounds alone for 6 months or a combination at lower doses for 24 months. The combination of pirenzepine (75 mg/day) and cimetidine (400 mg/day) was successful in a high percentage of cases, and showed fewer side effects than in the single treatment groups. The effectiveness of the combination treatment might be due to its more significant anti-secretory effects.
在一项长期研究中评估了用哌仑西平和西咪替丁联合治疗“无反应者”消化性溃疡的效果。对先用西咪替丁（1克/天）治疗两个月，然后用哌仑西平（150毫克/天）治疗两个月仍无反应的患者，单独给予这两种药物之一治疗6个月，或给予较低剂量联合治疗24个月。哌仑西平（75毫克/天）和西咪替丁（400毫克/天）联合治疗在高比例病例中取得成功，且副作用比单药治疗组少。联合治疗的有效性可能归因于其更显著的抗分泌作用。
