Gmerek D E, Cowan A, Vaught J L
Eur J Pharmacol. 1983 Oct 14;94(1-2):141-3. doi: 10.1016/0014-2999(83)90451-x.
When bombesin is given intracerebroventricularly to rats, it is known to cause excessive scratching and inhibit gastrointestinal transit. We have administered bombesin via a permanent indwelling cannula into the subarachnoid space of the lumbar spinal cord of rats. By this route, bombesin elicited immediate excessive scratching and rapidly inhibited passage of a charcoal meal along the gastrointestinal tract. The A50 values for these effects were 0.004 (0.001-0.018) micrograms/rat and 0.34 (0.22-0.55) micrograms/rat, respectively. Bombesin-induced scratching and inhibition of transit are therefore mediated at spinal, as well as supraspinal, levels.
当向大鼠脑室内注射蛙皮素时，已知会引起过度抓挠并抑制胃肠蠕动。我们通过一根永久性留置套管将蛙皮素注入大鼠腰段脊髓的蛛网膜下腔。通过这种途径，蛙皮素引发了立即的过度抓挠，并迅速抑制了木炭餐在胃肠道中的通过。这些效应的半数有效量（A50）值分别为0.004（0.001 - 0.018）微克/大鼠和0.34（0.22 - 0.55）微克/大鼠。因此，蛙皮素诱导的抓挠和对胃肠蠕动的抑制是在脊髓以及脊髓以上水平介导的。
