Coulaud J P, Larivière M, Gervais M C, Gaxotte P, Aziz A, Deluol A M, Cenac J
Bull Soc Pathol Exot Filiales. 1983 Nov;76(5):681-8.
Twenty immigrants from Mali and West Senegal were treated in Paris. Onchocerciasis was diagnosed by six skin snips using a Holth punch. Ivermectine was given in a single oral dose: ten patients were given 50 mcg/kg, three were given 75 mcg/kg and seven received 100 mcg/kg. No patients had ocular symptoms. The results were as follows: Pruritus disappeared rapidly in 9 out of 11 patients who itched before treatment. The microfilarial load decreased rapidly, especially in cases treated with 75 mcg/kg and 100 mcg/kg as all patients tested on day 60 were negative. Clinical signs of the Mazzotti reaction and ocular reactions were not observed following the treatment. Pruritus was briefly aggravated in only two patients. No cardiovascular, hematological, hepatic or renal toxicity was noted.
20名来自马里和塞内加尔西部的移民在巴黎接受治疗。使用霍尔思打孔器通过6次皮肤活检诊断盘尾丝虫病。伊维菌素采用单次口服给药：10名患者给予50微克/千克，3名患者给予75微克/千克，7名患者给予100微克/千克。所有患者均无眼部症状。结果如下：治疗前瘙痒的11名患者中，9名患者的瘙痒迅速消失。微丝蚴负荷迅速下降，尤其是在接受75微克/千克和100微克/千克治疗的患者中，因为在第60天检测的所有患者均为阴性。治疗后未观察到马佐蒂反应和眼部反应的临床体征。仅2名患者的瘙痒短暂加重。未发现心血管、血液、肝脏或肾脏毒性。
