Abemayor E, Kovachich G B, Haugaard N
J Neurochem. 1984 Jan;42(1):38-42. doi: 10.1111/j.1471-4159.1984.tb09694.x.
The action of dichloroacetate (DCA) on pyruvate dehydrogenase (PDH) activity of rat brain has been studied in vitro and in vivo. In a crude brain mitochondrial fraction, DCA inhibits PDH kinase and in rat brain slices this compound increases PDH activity and stimulates glucose oxidation. In the whole animal, intraperitoneal injection of DCA causes activation of brain PDH, indicating that this inhibitor crosses the blood-brain barrier. The same treatment with DCA also produced a large increase in heart PDH activity. Further studies of the effects of DCA on the CNS should lead to results of considerable importance.
已在体外和体内研究了二氯乙酸（DCA）对大鼠脑丙酮酸脱氢酶（PDH）活性的作用。在粗制的脑线粒体组分中，DCA抑制PDH激酶，并且在大鼠脑切片中，该化合物增加PDH活性并刺激葡萄糖氧化。在完整动物中，腹腔注射DCA可导致脑PDH活化，表明该抑制剂可穿过血脑屏障。用DCA进行相同处理也使心脏PDH活性大幅增加。对DCA对中枢神经系统影响的进一步研究应会得出相当重要的结果。
