Mills S E, Johns M E
Arch Otolaryngol. 1984 Jan;110(1):58-62. doi: 10.1001/archotol.1984.00800270062016.
A 68-year-old man had an 11-year history of a recurring carcinoid tumor of the larynx. In six additional examples of this uncommon neoplasm, cervical lymph node metastases were present in four patients and osseous involvement developed in another. Two patients died of their disease, one died without evidence of neoplasm, and four were living and clinically free of tumor at last follow-up. Laryngeal carcinoids are often atypical histologically and may be misdiagnosed as undifferentiated carcinoma, prompting inappropriate radiation therapy for a radiation-resistant neoplasm. Histologic features suggestive of carcinoid include a nesting or trabecular growth pattern and prominent perineural invasion. Argyrophil stains were positive in four of five cases. Ultrastructurally, these neoplasms have abundant dense core granules.
一名68岁男性有复发性喉类癌11年病史。在另外6例这种罕见肿瘤中，4例患者出现颈部淋巴结转移，另1例发生骨受累。2例患者死于该病，1例死亡时无肿瘤证据，4例存活，最后一次随访时临床无肿瘤。喉类癌在组织学上常不典型，可能被误诊为未分化癌，从而导致对放疗抵抗的肿瘤进行不适当的放射治疗。提示类癌的组织学特征包括巢状或小梁状生长模式以及显著的神经周围浸润。5例中有4例嗜银染色呈阳性。超微结构上，这些肿瘤有丰富的致密核心颗粒。
