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新皮层切除术后大鼠丘脑的2-脱氧葡萄糖摄取及组织学变化

2-Deoxyglucose uptake and histologic changes in rat thalamus after neocortical ablations.

作者信息

Cooper R M, Thurlow G A, Rooney B J

出版信息

Exp Neurol. 1984 Jan;83(1):134-43. doi: 10.1016/0014-4886(84)90052-9.

DOI:10.1016/0014-4886(84)90052-9
PMID:6690313
Abstract

2-Deoxy[14C]glucose (2-DG) uptake was examined in pentobarbital-anesthetized rats that 3 days to 2 years earlier had sustained large posterior neocortical ablations. At 2 weeks postoperatively 2-DG uptake was pronounced in those thalamic nuclei with cortical projection zones included in the ablated region. At shorter postoperative intervals (3 to 4 days) there appeared to be no increases in 2-DG uptake in these thalamic nuclei and at longer postoperative intervals (greater than 1 month) increases were only discernible in calcified sites. Both temporal and spatial postoperative variations in 2-DG uptake were found to coincide almost perfectly with glial cell proliferation and staining in the affected regions.

摘要

在戊巴比妥麻醉的大鼠中检测了2-脱氧[14C]葡萄糖(2-DG)摄取情况,这些大鼠在3天至2年前曾接受过大面积的后新皮层切除手术。术后2周时,在那些其皮质投射区包含在切除区域内的丘脑核中,2-DG摄取明显增加。在术后较短间隔时间(3至4天),这些丘脑核中的2-DG摄取似乎没有增加,而在术后较长间隔时间(大于1个月),仅在钙化部位可观察到摄取增加。发现2-DG摄取在术后的时间和空间变化几乎与受影响区域的胶质细胞增殖和染色完全一致。

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2-Deoxyglucose uptake and histologic changes in rat thalamus after neocortical ablations.新皮层切除术后大鼠丘脑的2-脱氧葡萄糖摄取及组织学变化
Exp Neurol. 1984 Jan;83(1):134-43. doi: 10.1016/0014-4886(84)90052-9.
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2-Deoxyglucose uptake in the thalamus of awake rats after neocortical ablations.新皮层切除后清醒大鼠丘脑对2-脱氧葡萄糖的摄取。
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