Cooper R M, Thurlow G A
Exp Neurol. 1984 Nov;86(2):261-71. doi: 10.1016/0014-4886(84)90185-7.
Local, temporary or permanent depressions and elevations in 2-deoxy[14C]glucose (2-DG) uptake were observed in the brains of unanesthetized, freely moving rats that 3 days to 1 year earlier had sustained large unilateral posterior neocortical ablations. Some of the differences in metabolic activity between the normal and damaged hemispheres, in both cortical and subcortical regions, were attributed to cell death and gliosis, and surgical trauma. In addition, it appeared that certain metabolic changes provided a physiologic correlate of diaschisis, a temporary impairment in function which von Monakow hypothesized to occur in neurons denervated by a lesion. We concluded that the 2-DG technique is a useful tool for examining the widespread effects of brain damage, and that when employed in the manner exemplified by this and a previous study, the technique can disentangle the changes in neural activity which occur after brain damage from the changes in glial activity which accompany them.
在3天至1年前遭受大面积单侧后新皮层切除的未麻醉、自由活动大鼠的大脑中，观察到2-脱氧[14C]葡萄糖（2-DG）摄取出现局部、暂时或永久性的降低和升高。正常半球与受损半球之间在皮质和皮质下区域的代谢活性差异，部分归因于细胞死亡、胶质增生和手术创伤。此外，某些代谢变化似乎为交叉性神经机能联系不能提供了生理关联，交叉性神经机能联系不能是一种功能暂时受损，冯·莫纳科夫推测其发生在因损伤而失去神经支配的神经元中。我们得出结论，2-DG技术是研究脑损伤广泛影响的有用工具，并且当以本研究及先前一项研究为例的方式使用该技术时，它可以将脑损伤后发生的神经活动变化与伴随的胶质活动变化区分开来。
