登革病毒感染迟发型超敏反应中效应细胞的Lyt表型和H-2相容性要求。
Lyt phenotype and H-2 compatibility requirements of effector cells in the delayed-type hypersensitivity response to dengue virus infection.
作者信息
Pang T, Devi S, Yeen W P, McKenzie I F, Leong Y K
出版信息
Infect Immun. 1984 Jan;43(1):429-31. doi: 10.1128/iai.43.1.429-431.1984.
Abstract
The nature of effector cells which mediate delayed-type hypersensitivity (DTH) to dengue type 2 virus and the influence of the H-2 complex on the cellular transfer of DTH was investigated. The DTH effector cells appeared to consist of two types of T cells, one Lyt-1.1+, the other Lyt-2.1+ or, alternatively, an interaction between these two T cell subsets may be required for maximal expression of DTH. Cellular transfer of DTH reactivity also required compatibility at the K and D or I region of the H-2 complex. Compatibility at the D region alone was not sufficient for transfer of DTH. The significance and implications of these findings are discussed.
摘要
研究了介导对2型登革病毒迟发型超敏反应（DTH）的效应细胞的性质以及H-2复合体对DTH细胞转移的影响。DTH效应细胞似乎由两种类型的T细胞组成，一种是Lyt-1.1+，另一种是Lyt-2.1+，或者，这两个T细胞亚群之间的相互作用可能是DTH最大表达所必需的。DTH反应性的细胞转移还需要H-2复合体的K和D或I区域的相容性。仅D区域的相容性不足以进行DTH的转移。讨论了这些发现的意义和影响。
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