Perez V J, Thach B B, Palet J L
Dev Psychobiol. 1978 Jul;11(4):301-8. doi: 10.1002/dev.420110403.
The S-100 protein was measured in 7 discrete brain areas from rats raised in an enriched, social, or isolated environment for 21, 42, or 84 days after weaning. S-100 was measured at significantly higher concentrations under enriched than under social environmental conditions in cerebellum and brainstem at 21 days but not thereafter. The protein in corresponding areas of brain in isolates was significantly less concentrated than in social controls. The results suggest changes, in turnover of the protein as a result of stimulation and activation of functionally specific brain regions, of the animals' responses to and interaction with environmental stimuli and adaptation to those stimuli.
在断奶后于丰富环境、社交环境或隔离环境中饲养21天、42天或84天的大鼠的7个离散脑区中测量了S-100蛋白。在21天时，小脑和脑干中S-100的测量浓度在丰富环境下显著高于社交环境，但之后并非如此。隔离饲养的大鼠相应脑区中的该蛋白浓度显著低于社交对照组。结果表明，由于功能特异性脑区的刺激和激活，该蛋白的更新发生了变化，动物对环境刺激的反应和相互作用以及对这些刺激的适应也发生了变化。
