Castresana M, Lee K Y, Chey W Y, Yajima H
Digestion. 1978 Jul-Aug;17(4):300-8. doi: 10.1159/000198123.
In conscious dogs prepared with gastric cannulae and antral and duodenal electrodes, intravenous administration of synthetic porcine motilin and CCK-OP in varying doses resulted in significant increases in the mean percent frequency of spike potentials on slow waves. Motilin was a more potent stimulant than CCK-OP. Motilin-stimulated spike potentials in both antrum and duodenum were significantly suppressed by either natural porcine secretin or synthetic porcine GIP. Secretin suppressed the spike potentials of the antrum stimulated by CCK-OP but not those of the duodenum. The spike potentials stimulated by CCK-OP could not be suppressed by GIP in the dosages employed.
在配备胃插管以及胃窦和十二指肠电极的清醒犬中，静脉注射不同剂量的合成猪胃动素和胆囊收缩素八肽（CCK-OP）会导致慢波上动作电位的平均频率百分比显著增加。胃动素比CCK-OP是更强效的刺激物。胃动素刺激的胃窦和十二指肠中的动作电位，可被天然猪促胰液素或合成猪胃抑肽显著抑制。促胰液素抑制CCK-OP刺激的胃窦动作电位，但不抑制十二指肠的动作电位。在所使用的剂量下，胃抑肽不能抑制CCK-OP刺激的动作电位。
