通过γ射线预处理抑制ICR - 2A蛙细胞中紫外线诱导的姐妹染色单体交换。
Inhibition of the UV induction of sister-chromatid exchanges in ICR-2A frog cells by pretreatment with gamma-rays.
作者信息
Chao C C, Rosenstein B S
出版信息
Mutat Res. 1984 Jan;139(1):35-9. doi: 10.1016/0165-7992(84)90119-2.
Exposure of ICR-2A cells to UV induced the formation of sister-chromatid exchanges (SCEs). However, pretreatment of UV-irradiated cells with gamma-rays resulted in a reduction in the level of SCEs. This effect was observed over a range of UV fluences (1-5 J/m2) and gamma-ray doses (50-500 rad). In addition, the depression of UV-induced SCEs was greatest when the UV treatment was preformed within 3 h after gamma-irradiation. At later times the level of SCEs approached that of cells exposed only to UV.
将ICR - 2A细胞暴露于紫外线会诱导姐妹染色单体交换（SCEs）的形成。然而，用γ射线对紫外线照射的细胞进行预处理会导致SCEs水平降低。在一系列紫外线通量（1 - 5 J/m²）和γ射线剂量（50 - 500拉德）范围内均观察到了这种效应。此外，当在γ射线照射后3小时内进行紫外线处理时，紫外线诱导的SCEs的抑制作用最为显著。在之后的时间里，SCEs水平接近仅暴露于紫外线的细胞的水平。
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