Han T, Ozer H, Sadamori N, Emrich L, Gomez G A, Henderson E S, Bloom M L, Sandberg A A
N Engl J Med. 1984 Feb 2;310(5):288-92. doi: 10.1056/NEJM198402023100504.
Chronic lymphocytic leukemia is recognized as having a variable prognosis, but its staging has depended exclusively on anatomical sites of involvement and the presence or absence of anemia and thrombocytopenia. The recent availability of techniques permitting cytogenetic analysis of malignant B lymphocytes led us to examine the karyotypic abnormalities in chronic lymphocytic leukemia and to correlate them with clinical stage, progression of disease, and survival. Of 53 patients with metaphases adequate for study who were followed for a minimum of one year, 21 (40 per cent) had abnormal karyotypes, of which trisomy 12 was the most frequent (25 per cent). Abnormal karyotypes were found to be significant correlates of advanced clinical stage (P less than 0.005) and of shortened survival (P less than 0.05). We conclude that cytogenetic analysis provides useful clinical and prognostic information in patients with chronic lymphocytic leukemia.
慢性淋巴细胞白血病的预后被认为具有多样性，但其分期完全取决于受累的解剖部位以及贫血和血小板减少症的有无。最近可用于对恶性B淋巴细胞进行细胞遗传学分析的技术，促使我们研究慢性淋巴细胞白血病的核型异常，并将它们与临床分期、疾病进展及生存率联系起来。在53例至少随访一年且有适合研究的中期分裂相的患者中，21例（40%）有异常核型，其中12号染色体三体最为常见（25%）。发现异常核型与晚期临床分期（P<0.005）及生存期缩短（P<0.05）显著相关。我们得出结论，细胞遗传学分析可为慢性淋巴细胞白血病患者提供有用的临床和预后信息。
