Howie V M, Ploussard J, Sloyer J L, Hill J C
Pediatrics. 1984 Jan;73(1):79-81.
A total of 133 children between 6 and 11 months of age with at least one episode of otitis media were given one of two pneumococcal vaccines. One vaccine contained 25 microns of types 1, 3, 6, 7, 14, 18, 19, and 23 and the other vaccine (control) contained 25 microns of types 2, 4, 5, 8, 9, 12, and 25. Follow-up care of the 65 black infants revealed significantly more otitis media visits in those infants receiving the control vaccine. Among the 68 white infants there was no difference between control and vaccine groups after vaccination.
共有133名6至11个月大且至少患过一次中耳炎的儿童接种了两种肺炎球菌疫苗中的一种。一种疫苗含有25微克的1型、3型、6型、7型、14型、18型、19型和23型，另一种疫苗（对照）含有25微克的2型、4型、5型、8型、9型、12型和25型。对65名黑人婴儿的后续护理显示，接种对照疫苗的婴儿中耳炎炎就诊次数明显更多。在68名白人婴儿中，接种疫苗组和对照组在接种疫苗后没有差异。
