Törnquist C, Holtås S
Radiology. 1984 Feb;150(2):331-4. doi: 10.1148/radiology.150.2.6691084.
The nephrotoxicity of the ionic contrast medium metrizoate was compared with that of nonionic iohexol when used for renal angiography. Fifteen patients who underwent renal angiography with metrizoate and 15 with iohexol were studied. Serum creatinine level, Cr-51-EDTA clearance, and urine albumin level were recorded before and after angiography. Metrizoate affected renal function, as indicated both by a transient decrease in glomerular filtration rate and by a transient albuminuria. Renal function was unaffected by iohexol. Furthermore, iohexol produced less subjective discomfort than metrizoate. There appeared to be no difference in the quality of the angiograms obtained with the two media.
将离子型造影剂甲泛葡胺与非离子型碘海醇用于肾血管造影时的肾毒性进行了比较。研究了15例接受甲泛葡胺肾血管造影的患者和15例接受碘海醇肾血管造影的患者。记录了血管造影前后的血清肌酐水平、铬-51-乙二胺四乙酸清除率和尿白蛋白水平。甲泛葡胺影响肾功能，表现为肾小球滤过率短暂下降和短暂性蛋白尿。碘海醇对肾功能无影响。此外，碘海醇引起的主观不适比甲泛葡胺少。两种造影剂获得的血管造影片质量似乎没有差异。
